Fifteen Eighty Four


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  • 21 May 2024
    David C Henshall

    Secrets of our genome: Small RNAs conduct the molecular orchestra of life

    The actions of genes are fundamental to life as we know it. But how is your genome’s prodigious output controlled? What checks and balances ensure the right ‘amount’ of gene activity in each of your trillions of cells? What is conducting the molecular orchestra of life? Researchers have been unpicking the pathway from gene to […]

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  • 15 Apr 2024
    Professor Robert Hahn

    Infusion fluids and hemodynamics are eventually united.

    When going to my hospital work, I pass a well-kept peaceful and quite large grass area surrounded by a fence. A memory stone declares that this is a mass grave of cholera victims from the 1850s. As a researcher in fluid balance, I sometimes think about how little doctors knew about this topic 175 years […]

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  • 28 Feb 2024
    Elise C. Carey, Gordon J. Wood, Holly B. Yang

    A Practical Guide to Discussing What Matters Most with Seriously Ill Patients

    Navigating Communication with Seriously Ill Patients, Balancing Honesty with Empathy and Hope – The VitalTalk Method is a book written for all clinicians who want to communicate better with seriously ill patients and their family members.

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  • 15 Feb 2024
    Stanley Ulijaszek

    Obesity unpacked: a journey into complexity

    Most people have some dissatisfaction or concern about body weight, fatness, or obesity, either personally or professionally. I wrote ’Understanding Obesity’ out of a dissatisfaction with the dominant lines of investigation into this phenomenon, and the discourses that drive them. Sure, huge scientific progress has been made in understanding the physiology of eating and body […]

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  • 14 Feb 2024
    Jane Morris


    As I wrote my book Improving University Mental Health, the commonest question people asked was ‘who is the intended audience?’  If you are reading these words, then the answer is ‘you are!’   Did you go to university?  What was your experience of emerging into adult life?  What can we do better? Readers seeking simple answers will be […]

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  • 25 Jan 2024
    Patricia Casey, Brendan Kelly

    Fish’s Clinical Psychopathology (Fifth Edition)

    Psychopathology is fascinating. It is the science and study of psychological and psychiatric symptoms. A clear understanding of clinical psychopathology lies at the heart of effective delivery of psychiatric care. Psychopathology is essential. For many years, the central textbook in this field was a 128-page volume written in 1967 by Frank Fish, titled Clinical Psychopathology: […]

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  • 22 Jan 2024
    Rachel Thomasson, Allan House, Elspeth Guthrie

    Liaison psychiatry – where physical and mental healthcare meet

    Most people are familiar with the idea that there is an interaction between physical and mental health. Living with severe chronic illness or disability can have very marked psychological impact, and experience from the recent pandemic has shown how acute severe illness and its personal and social consequences can affect mental health. Other obvious examples […]

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  • 29 Nov 2023
    Adam Polnay, Rhiannon Pugh

    (Re)discovering the Basics of Therapy: A Continuing Process for Psychotherapists

    As clinicians involved in training and supervision, we have observed in others and ourselves how starting psychotherapy with a patient is often anxiety-provoking for both parties. This experience may leave new therapists in particular feeling de-skilled. Learning a new style of working can add to a feeling of being at sea. It is perfectly understandable […]

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