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The 2024 Nobel Prize in Physiology or Medicine was awarded on October 7th to Victor Ambros and Gary Ruvkun for their discovery of microRNAs (miRNAs). This ground-breaking finding transformed our understanding of how gene activity is controlled. I am the author of a new book on the topic: ‘Fine-Tuning Life: A guide to microRNAs, your […]
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A PROMISE THAT IS AT ONCE A CHALLENGE Gene editing offers great promise to reduce human misery and facilitate human health: to combat virus infectious diseases; to correct monogenic disorders in pluripotent cells; to program cells for regenerative medicine and cancer immunotherapy; to prevent parents’ transmitting serious genetic diseases to offspring; to correct mutations in […]
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The essence of biological complexity is communication - a transmission of information between the component parts of an association. But what is the nature of this information and how do genomes co-operate to form a complex web?
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Complexity is all about the evolution of the possible. I initially planned a simple account of the physical properties of DNA but I soon realised that that the concepts of DNA as an informational codescript, the nature of information itself and the rise of biological complexity are intextricably intertwined. The final incarnation is very far from the book I'd initially conceived but is an amalgam of an intellectual journey that took me to places of whose existence I was previously unaware.
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Wallace Arthur, author of Understanding Evo-Devo, sheds light on the way in which radically new animal forms arise in the course of evolution
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My previous blog summarised the orthodox argument why adverse selection in insurance is a bad thing. This present blog gives the counter-argument from my book Loss Coverage: Why Insurance Works Better with Some Adverse Selection. In essence, the counter-argument relies only on simple arithmetic, and can be illustrated by a toy example. Think of a […]
Read MoreGuy Thomas explores why adverse selection in insurance is usually seen as a bad thing in the first of two blog posts based on his new book Loss Coverage.
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Graeme Finlay, the author of Human Evolution: Genes, Genealogies and Phylogenies, describes the complex ways in which cells—and thus entire species—are related to one another.
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